An Explicit Spatial Model of Yeast Microcolony Growth
نویسندگان
چکیده
Here we present a single-cell-based model of cell-cell interactions in a growing yeast colony. We examine the influence of multiple factors on the colony morphology and switch to a foraging growth behavior. We find that the cell-growth inhibition by neighboring cells along with polar division growth patterns are the most significant factors driving the exploratory behavior of a colony.
منابع مشابه
One-Cell Doubling Evaluation by Living Arrays of Yeast, ODELAY!
Cell growth is a complex phenotype widely used in systems biology to gauge the impact of genetic and environmental perturbations. Due to the magnitude of genome-wide studies, resolution is often sacrificed in favor of throughput, creating a demand for scalable, time-resolved, quantitative methods of growth assessment. We present ODELAY (One-cell Doubling Evaluation by Living Arrays of Yeast), a...
متن کاملAnalysis of urban growth pattern using logistic regression modeling, spatial autocorrelation and fractal analysis Case study: Ahvaz city
Transformation of land use-land cover change occurs due to the numbers and activities of people. Urban growth modeling has attracted authentic attention because it helps to comprehend the mechanisms of land use change and thus helps relevant policies made. This study applied logistic regression to model urban growth in the Ahvaz Metropolitan Area of Khuzestan province in IDRISI Selva software a...
متن کاملExperimental and mathematical study of the influence of growth factors on the growth kinetics of adult human articular chondrocytes.
This study aimed at determining how kinetic parameters of adult human articular chondrocytes (AHAC) growth are modulated by the growth factor combination TGFbeta1, FGF-2, and PDGF BB (TFP), recently shown to stimulate AHAC proliferation. AHAC, isolated from cartilage biopsies of three individuals, were cultured in medium without (CTR) or with TFP. For growth curves, AHAC were seeded at 1,000 ce...
متن کاملRole of Mutation in Pseudomonas aeruginosa Biofilm Development
The survival of bacteria in nature is greatly enhanced by their ability to grow within surface-associated communities called biofilms. Commonly, biofilms generate proliferations of bacterial cells, called microcolonies, which are highly recalcitrant, 3-dimensional foci of bacterial growth. Microcolony growth is initiated by only a subpopulation of bacteria within biofilms, but processes respons...
متن کاملMicrocolony and biofilm formation as a survival strategy for bacteria.
Bacterial communities such as biofilms are widely recognized as being important for survival and persistence of bacteria in harsh environments. Mechanistic models of biofilm growth indicate that the way in which the surface is seeded can effect the morphology of simulated biofilms. Experimental studies indicate that genes which are important for chemotaxis also influence biofilm formation, perh...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Multiscale Modeling & Simulation
دوره 3 شماره
صفحات -
تاریخ انتشار 2005